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KMID : 0370219970410060765
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Yakhak Hoeji
1997 Volume.41 No. 6 p.765 ~ p.772
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Active Conformation of Thromboxane A2 and Thromboxane A2 Receptor Antagonists
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이종달/RheeJD
도성탁/Doh ST
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Abstract
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Conformational analyses on thromboxane A2 (TxA2) and thromboxane A2 receptor antagonists (TxRA) were carried out by molecular mechanics method. Based on the assumption that active conformer is the nonintrahydrogen bonding and more stable former of TxA2 and TxRA, the molecular structural requirements for potent TxA2 receptor antagonists are like below: 1) The distance is 5.0-5.6 A.U. between C atom of carboxyl group and S atom of sulfonyl group or C atom which is bonded to hydroxyl group in the active conformers. 2) The putative active conformers of TxA2 and TxRAs are hairpin-like forms.
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KEYWORD
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FullTexts / Linksout information
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Listed journal information
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